dc.contributor.author |
Omwoyo, Wesley N. |
|
dc.contributor.author |
Paula, Melariri |
|
dc.contributor.author |
Gathirwa, Jeremiah W. |
|
dc.contributor.author |
Oloo, Florence |
|
dc.contributor.author |
Mahanga, Geoffrey M. |
|
dc.contributor.author |
Kalombo, Lonji |
|
dc.contributor.author |
Ogutu, Bernhards |
|
dc.contributor.author |
Hulda, Swai |
|
dc.date.accessioned |
2017-05-19T13:38:32Z |
|
dc.date.available |
2017-05-19T13:38:32Z |
|
dc.date.issued |
2016-04 |
|
dc.identifier.citation |
https://doi.org/10.1016/j.nano.2015.11.017 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/123456789/4782 |
|
dc.description |
Abstract |
en_US |
dc.description.abstract |
Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA into solid lipid nanoparticles (SLNs) as a nanomedicine drug delivery system. DHA-SLNs were characterized for physical parameters and evaluated for in vitro and in vivo antimalarial efficacy. DHA-SLNs showed desirable particle characteristics including particle size (240.7 nm), particle surface charge (+ 17.0 mV), drug loadings (13.9 wt %), encapsulation efficacy (62.3%), polydispersity index (0.16) and a spherical appearance. Storage stability up to 90 days and sustained release of drug over 20 h was achieved. Enhanced in vitro (IC50 0.25 ng/ml) and in vivo (97.24% chemosuppression at 2 mg/kg/day) antimalarial activity was observed. Enhancement in efficacy was 24% when compared to free DHA. These encouraging results show potential of using the described formulation for DHA drug delivery for clinical application. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Science direct |
en_US |
dc.subject |
dihydroartemisinin |
en_US |
dc.subject |
solid lipid nanoparticles |
en_US |
dc.subject |
nanomedicine drug delivery |
en_US |
dc.title |
Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles |
en_US |
dc.type |
Article |
en_US |